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KMID : 0390220010120010083
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2001 Volume.12 No. 1 p.83 ~ p.88
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A case of Oropharyngeal T/NK-Cell Lymphoma with Hemophagocytic Syndrome
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전은주/Eun Ju Jeon
최영철/박용수/김경미/Young Chul Choi/Young Soo Park/Kyoung Mee Kim
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Abstract
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T/NK-cell lymphoma (TNKL) is a subtype of angiocentric T-cell lymphoma showing the characteristics of biphenotype of T-cell and NK-cell, frequent association with Epstein-Barr virus (EBV), and poor clinical course. It usually develops in nasal
cavity,
paranasal sinus, and nasopharynx. Hemophagocytotic syndrome is a histiocytic proliferation associated with phagocytosis of the hemopoietic elements resulting in fever, profound pancytopenia, hepatosplenomegaly, lymphadenopathy, and coagulopathy.
It
is
considered as a negative prognostic factor for hematologic neoplasms. Epstein-Barr virus infection is considered as pathogenic factor for hemophagocytotic syndrome. We experienced a case of EBV-infected oropharyngeal lymphoma of T/NK-cell
lymphoma
associated with hemophagocytotic syndrome, which was confirmed by immunohistochemical study, in situ hybridization, and bone marrow biopsy. We report this case with brief review of literatures.
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